Pitavastatin calcium

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Pitavastatin calcium is a novel member of the medication class of statins.

Pitavastatin calcium is a novel member of the medication class of statins. The statins are a family of compounds that inhibit 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase, a pivotal enzyme in cholesterol biosynthesis. Pitavastatin is a potent inhibitor of HMG-CoA reductase (Ki = 1.7 nM). It lowers both total cholesterol and low density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cytochrome P450 system is minimal, reducing the risk of drug-drug interactions. Moreover, pitavastatin causes atherosclerosis regression in humans with subclinical carotid atherosclerosis and improves cardiac function and survival in a rat model of hypertensive heart failure.

Itabastatin; Itavastatin; NK 104

Others

Other Targets

cholesterol esters

Cancer

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147526-32-7

880.98

C50H46CaF2N2O8

>98%(HPLC)

DMSO: 51 mg/mL (57.89 mM)

C1C(C1)C2=NC3=CC=CC=C3C(=C2/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])C4=CC=C(C=C4)F.C1C(C1)C2=NC3=CC=CC=C3C(=C2/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])C4=CC=C(C=C4)F.[Ca+2]

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(-20℃)

With Ice Pack

≥ 2 years