
Pitavastatin calcium
CAS No. 147526-32-7
Pitavastatin calcium ( Itabastatin | Itavastatin | NK 104 )
产品货号. M12034 CAS No. 147526-32-7
Pitavastatin Calcium (NK-104 hemicalcium) 是有效的羟甲基戊二酰-CoA (HMG-CoA) 还原酶抑制剂。Pitavastatin Calcium 在 HepG2 细胞中抑制乙酸合成胆固醇的 IC50 为 5.8 nM。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥275 | 有现货 |
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10MG | ¥437 | 有现货 |
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25MG | ¥616 | 有现货 |
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50MG | ¥794 | 有现货 |
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100MG | ¥1385 | 有现货 |
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200MG | ¥1936 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Pitavastatin calcium
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Pitavastatin Calcium (NK-104 hemicalcium) 是有效的羟甲基戊二酰-CoA (HMG-CoA) 还原酶抑制剂。Pitavastatin Calcium 在 HepG2 细胞中抑制乙酸合成胆固醇的 IC50 为 5.8 nM。
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产品描述Pitavastatin calcium is a novel member of the medication class of statins. The statins are a family of compounds that inhibit 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase, a pivotal enzyme in cholesterol biosynthesis. Pitavastatin is a potent inhibitor of HMG-CoA reductase (Ki = 1.7 nM). It lowers both total cholesterol and low density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cytochrome P450 system is minimal, reducing the risk of drug-drug interactions. Moreover, pitavastatin causes atherosclerosis regression in humans with subclinical carotid atherosclerosis and improves cardiac function and survival in a rat model of hypertensive heart failure.(In Vitro):Pitavastatin Calcium inhibits the growth of a panel of ovarian cancer cells, including those considered most likely to represent HGSOC, grown as a monolayers (IC50?=?0.4-5?μM) or as spheroids (IC50=0.6-4?μM).Pitavastatin Calcium (1 μM; 48 hours ) induces apoptosis, evidenced by the increased activity of executioner caspases-3,7 as well as caspase-8 and caspase-9 in Ovcar-8 cells and Ovcar-3 cells.Pitavastatin (1?μM, 48?hours) causes PARP cleavage in Ovcar-8 cells.(In Vivo):Pitavastatin Calcium (59?mg/kg; p.o.; twice daily for 28 days) causes significant tumour regression.
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体外实验Western Blot Analysis Cell Line:Ovcar-8 cells Concentration:1?μM Incubation Time:48 hours Result:Induced PARP cleavage.
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体内实验Animal Model:4 week old female NCR Nu/Nu female mice?(bearing Ovcar-4 tumours)Dosage:59?mg/kg Administration:p.o.; twice daily for 28 days Result:Caused significant tumour regression.
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同义词Itabastatin | Itavastatin | NK 104
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通路Others
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靶点Other Targets
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受体cholesterol esters
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研究领域Cancer
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适应症——
化学信息
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CAS Number147526-32-7
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分子量880.98
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分子式C50H46CaF2N2O8
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纯度>98% (HPLC)
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溶解度DMSO: 51 mg/mL (57.89 mM)
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SMILESC1C(C1)C2=NC3=CC=CC=C3C(=C2/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])C4=CC=C(C=C4)F.C1C(C1)C2=NC3=CC=CC=C3C(=C2/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])C4=CC=C(C=C4)F.[Ca+2]
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Ahmad H, et al. Cardiol Rev, 2010, 18(5):264-267.
产品手册




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